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Apigenin 7-glucoside

Name: Apigenin 7-glucoside
Brand: TargetMol
SKU: T4S0295
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4S0295Cas No. 578-74-5

Alias Thalictiin, Cosmosioside, Cosmosiin, Cosmetin, Apigetrin, Apigenin-7-O-β-D-glucopyranoside

1. Apigenin 7-glucoside (Cosmosiin) is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.

Apigenin 7-glucoside

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Purity: 99.79%

Catalog No. T4S0295Alias Thalictiin, Cosmosioside, Cosmosiin, Cosmetin, Apigetrin, Apigenin-7-O-β-D-glucopyranosideCas No. 578-74-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$129	In Stock	In Stock
50 mg	$213	In Stock	In Stock
100 mg	$347	-	In Stock
500 mg	$823	-	In Stock
1 g	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Apigenin 7-glucoside AI Summary

Apigenin 7-glucoside exhibits a broad spectrum of bioactivities including antiviral, anticancer, anti-inflammatory, antioxidant, antimicrobial, cytotoxic, neuroprotective, and enzyme inhibitory activities. It shows significant inhibitory activity against HIV-1 replication in the H9 cell line (EC50 = 1.8 µg/mL) and has a high therapeutic index (>55.6), suggesting favorable therapeutic potential. This compound also demonstrates growth inhibition against multiple human cancer cell lines and a GI50 value of 76.0 nM in an NCI's anticancer drug screening program. Apigenin 7-glucoside inhibits cow milk xanthine oxidase (13.9% inhibition at 50 µg/mL), activates both human plasma alternative and guinea pig classical complement systems, and displays antioxidant properties, with an IC50 for AAPH-induced hemolysis in rat red blood cells at 88400 nM. It shows antimutagenic, antiestrogenic, and anti-inflammatory activities, such as inhibiting LPS-induced nitrite accumulation in mouse RAW264.7 cells (IC50 > 20000 nM). Antiviral properties include inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells and 9.44% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. Additionally, this compound exhibits potent antifungal activities, significant cytotoxicity to various cell lines such as KB, HL, and HepG2 cells, and acts as an inhibitor of several enzymes including alpha-glucosidase, neuraminidase, and OATP transporters. It also shows hepatoprotective effects under oxidative stress conditions and neuroprotective activity against glutamate-induced cell death in HT-22 cells. Such wide-ranging bioactivities make Apigenin 7-glucoside a promising candidate for further investigation in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Apigenin 7-glucoside (Cosmosiin) is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
Synonyms	Thalictiin, Cosmosioside, Cosmosiin, Cosmetin, Apigetrin, Apigenin-7-O-β-D-glucopyranoside

Chemical Properties

Molecular Weight	432.38
Formula	C₂₁H₂₀O₁₀
Cas No.	578-74-5
Smiles	OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.642g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (583.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3128 mL	11.5639 mL	23.1278 mL	115.6390 mL
5 mM	0.4626 mL	2.3128 mL	4.6256 mL	23.1278 mL
10 mM	0.2313 mL	1.1564 mL	2.3128 mL	11.5639 mL
20 mM	0.1156 mL	0.5782 mL	1.1564 mL	5.7820 mL
50 mM	0.0463 mL	0.2313 mL	0.4626 mL	2.3128 mL
100 mM	0.0231 mL	0.1156 mL	0.2313 mL	1.1564 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc